Rabies immunoglobulin dose calculation. Please confirm patient weight (wt.

Rabies immunoglobulin dose calculation It is indigenously manufactured; to be used only after skin sensitivity test as per product insert. In no cases should the dosage of the rabies immunoglobulin be exceeded because immunoglobulin may partially suppress active production of antibodies. 05, SHORT REPORT Injecting rabies immunoglobulin (RIG) into wounds only: A significant saving of lives and costly RIG Omesh Kumar Bharti a, Shampur Narayan Madhusudana b, and Henry Wildec aState Intra-dermal Anti-rabies Clinic and Research Centre, DDU Zonal Hospital Shimla, Government of Himachal Pradesh, Shimla, India; bWHO- Collaborating Centre for Reference RIG Rabies immunoglobulin SA South Africa WHO World Health Organization IV. This is called post-exposure prophylaxis. NB: All animal bites in forest or all wild animal bite should be treated as Category III exposures. The predecessor product, HYPERRAB ® S/D [rabies immune globulin (human)] was formulated at 150 IU/mL. 212/2, Hadapsar, Off Soli Poonawalla Road, Pune 411028 India . In the United States, an average of three human rabies cases have occurred annually since 2000, and almost 30 percent of those were imported cases due 2. 3 Regimen for rabies immunoglobulin (RIG) administration 4 2. Joseph Torresi, Herwig Kollaritsch, in Travel Medicine (Fourth Edition), 2019. • Infiltrate the area around and into the wound(s), if anatomically The human rabies immunoglobulin (HRIG) is a life-saving immune biological essential for all category III animal exposures. RIG is given for risk category 3 only. U. Last EML RIG is listed under human immunoglobulin 11. 2 Intramuscular (IM) Regimen 2. 2010;59(RR-2):1-9. Presently the dose of rabies immunoglobulin (RIG) which is an integral part of rabies post exposure prophylaxis (PEP) is calculated based on body weight though the recommendation is to infiltrate the wound(s). Thus, level of circulating antibodies was the determining factor for dose calculation of RIG, while the wound size and local neutralizing effect were not considered in dose definition. 0 mL dose of rabies vaccine is given IM in the deltoid area of adults or the anterolateral thigh of young children on Days 0, 3, 7, and 14 of the rabies PEP regimen *Note: HyperRab has a different concentration compared to the other immunoglobulin products and requires a lower volume to administer the recommended dose of 20 IU/kg. 1 Mucosal exposure 4 2. Human rabies immunoglobulin. Human rabies immunoglobulin (Berirab P), which was Rabies vaccines and immunoglobulins: WHO position SUMMARY OF 2017 UPDATES These updated recommendations are based on new evidence and directed by public health needs that are cost-, dose- and time-sparing, while assuring safety and clinical effectiveness. Late doses mean delayed protection and the timing of subsequent doses must be adjusted to respect the minimum intervals. 00 900 6. Citation 2 Infection in humans begins at viral inoculation, most commonly from saliva first dose of the vaccine should be inoculated at the same time as the immunoglobulin, but in different parts of the body. The doses of HRIG needed for infiltration of bite wounds were recorded for all the patients. Updated with version 2. 01 IU could neutralize this amount of virus Control Manual, Chapter 1: Rabies, section 4. 1 Intradermal (ID) Regimen 2. There are two classes of rabies passive immunizing agents: 1. Rabies immunoglobulin is not needed for these individuals. It provides neutralizing antibodies at the site of exposure until the body can produce vaccine-mediated antibodies. rabies virus at the wound site until rabies vaccine, which should be given at a separate site at the same time, becomes effective. 1 (Section 11: INTRODUCTION. Home; About Us; Products. The All animal bite victims should be given proper wound care and timely and full doses of any modern anti-rabies vaccine. 5 ml (40 IU/ml) vial Immunoglobulin (RIG), obtained from humans (hRIG) or equines (eRIG), are the only immunoglobulins presently available for managing unprotected “Window Periods” in severely rabies exposed patients. 2 July 2018. [10] It is given by injection into the site of the wound and into a muscle. 1. The polyclonal RIG is relatively easy to produce, possesses high potency, a broad 2. The first dose of the vaccine should be inoculated at the same time as the immunoglobulin, but in different parts of the body. PEP involves thorough wound care along with Rabies immunoglobulin – polyclonal. If there is a delay, initiate post-exposure prophylaxis at any time after exposure. RABIES IMMUNOGLOBULIN: Brief history and recent experiences in Côte d'Ivoire. Citation 1 Rabies virus, a genus of Lyssavirus from the Rhabdoviridae family, persists in nature largely in wildlife reservoirs with geographic specificity. If the calculated dose of RIG is insufficient to infiltrate all wounds, sterile saline may be used to This animated video provides step-by-step visual guidance on how to properly dose and administer KEDRAB to previously unvaccinated patients – for immediate protection from the rabies virus. [10] It is given after the wound is cleaned with soap and water or povidone-iodine and is followed by a course of rabies vaccine. Either intramuscular (0. A. Similarly, two types of rabies immunoglobulin were used in the study viz. 11 Adverse reactions to RIGs 16 Rabies Immunoglobulin (RIG) is a life saving drug in all category III exposures. Locations: Abu Dhabi | Canada | Florida | London | Nevada | Ohio | 800. This vaccine partially The study is entitled; “Assessment of rabies immune globulin dose rounding at a university health system. Introduction: World Health Organization has recommended that in healthy persons with category III exposures, who receive wound care and rabies immunoglobulin infiltration, a vaccine regimen consisting of 4 doses administered intramuscularly on days 0, 3, 7, and 14 can be used as an alternative to the 5-dose intramuscular regimen. RIG should not be administered in the same Equirab 1500 Injection should be administered into the muscle (the intramuscularly). [10] It is used to prevent rabies following exposure. Human rabies immunoglobulin (HRIG) should be stored in a refrigerator between +2°C and +8°C. . ii. Administer anti-rabies vaccine immediately Stop treatment if dog/cat remains healthy if Doses only on day 0 and 3 (these actually serve as booster doses). Table 1: Equine rabies immunoglobulin currently manufactured in India Updated Administration of rabies vaccine and immunoglobulin. Dose Calculation for Maximum RIG volume based on weight of client: NOTE: three different RIG products currently Five doses of 1. There are two types of RIG. Rabies vaccination provides long-lasting immunity. In a person who was previously appropriately vaccinated against rabies: only two doses of rabies vaccine are required which are given on Days 0 and 3. However, should a delay occur, administer KEDRAB at any time up to and including seven days after the first dose of rabies vaccine. Use Caution/Monitor. There were 54 estimates of immune responses to vaccination, which showed that Single-dose vials of rabies vaccine should be reconstituted with accompanying sterile diluent to a final volume of 1mL before administration. 12 Equine rabies immunoglobulin Dose is 40 IU/Kg (hRIG is 20 IU/Kg) 9. Imogam and KamRAB are supplied in 2 mL vials (150 IU/mL). Additional doses of rabies vaccine should be given according to official guidelines or the manufacturer's instructions. Administer KEDRAB as soon as possible after exposure, preferably Dose Calculation for Maximum RIG volume based on weight of client: NOTE: three different RIG products currently available: calculations will be based on product availability • For 1ml vial HyperRAB® S/D human RabIg is supplied in 1 mL vials (300 IU/mL). Rabies PEP is not recommended in the event of repeat exposures (i. Rabies infection is serious and often fatal. Introduction. such as number of doses, and concomitant rabies immunoglobulin. Grifols. Rabies immunoglobulin (RIG) is a medication made up of antibodies against the rabies virus. If a large volume (> 2mL for children or > 5 mL for adults) is required, it is advised to divide the doses and for each dose a different site should be used. List of Experts 5. Calculate the volume of HYPERRAB for the recommended dose of 20 IU/kg. a) Area for injection for vaccine; no more than the recommended dose should be given. Rabies vaccine should be administered intramuscularly in the deltoid area for adults, in the deltoid or the anterolateral aspect, or in the thigh for children. DOSES AND SCHEDULE: B • The recommended dosage for children and adults is the same: 20 IU/kg of body weight. Use of a reduced (4-dose) vaccine schedule for postexposure prophylaxis to prevent human rabies: recommendations of the Advisory Committee on Immunization Practices. 11 Assuming a confidence interval of 95% and α = 0. Most of the RIG should be injected around the wound. The benefits of use of rabies immunoglobulin after exposure to Conclusions: This dose finding study demonstrates that priming with a single dose of rabies vaccine was sufficient to induce an adequate anamnestic antibody response to rabies PEP in all subjects at the time of the first rabies vaccine dose. Another study showed that rabies antibodies persisted for many years after ID PrEP, and an adequate antibody response could be expected 7 days after a single ID booster dose in more than 99% of participants; however, the participants in this study were vaccinated with a standard schedule (three 0. But rabies post-exposure prophylaxis (PEP) is also almost 100% effective at preventing disease. re Human Rabies Immunoglobulin is a human-derived rabies vaccine that is used to protect against rabies infection. • If there is a delay, initiate post-exposure prophylaxis at any time after exposure. 3. Rabies immunoglobulin and the first dose of rabies vaccine should be given as soon as possible after exposure. Enter the patient’s body weight, then press the CALCULATE button. rabies vaccine with or without rabies immunoglobulin) is highly effective in preventing disease if given correctly and promptly after exposure. ” We all understand how dangerous rabies is– killing almost 100% of people once symptoms start. Rabies immune globulin may be given on day zero with the first post-exposure dose in previously unvaccinated patients; not recommended for previously vaccinated patients. The benefits of use of rabies immunoglobulin after exposure to price of human rabies vaccine and the number of vaccine doses in humans; a 10 percent increase or decrease in these parameters, resulted in both cases in a 2 percent change in total costs. Risk assessment and management Trusts have all been asked to hold a small number of rabies vaccine doses (up to 4 per site) or to ensure they can access rabies For fully immunised individuals with an amber or red composite rabies risk, give 2 doses of rabies vaccine (first dose on day 0 and second dose between days 3–7). Infiltrate the entire immunoglobulin dose, or as much as possible (avoiding compression syndrome), in the depth and around the wounds. Rabies prophylaxis exclusively with simultaneous vaccination: recommended dose of rabies immunoglobulin is 20 IU/kg The dose of HRIG (human rabies immunoglobulin) is 20 IU per kilogram of body mass. A 1. Infiltrate as much of the dose as possible into and around the wound(s), which has been cleaned Calculate the dose of RabIg in mL: Ensure the total calculated dosage is administered but do not exceed. 47 42 1680 5. , Mumbai. Objective: To assess the Post-exposure prophylaxis consists of a regimen of one dose of immunoglobulin and full courses of rabies vaccination. RPEP rabies vaccine schedule Dose number Minimum interval from Rabies Immune Globulin Description. 9 Mode of Administration of full dose of RIGs 13 2. The volume required of HYPERRAB (300 IU/mL) to achieve the KamRAB is a human rabies immunoglobulin (HRIG) indicated for passive, transient post-exposure prophylaxis (PEP) of rabies infection, when given immediately after contact with a KamRAB should be administered at any time up to and including seven days after the first dose of vaccine. Doses of Rabies Immunoglobulins Weight Equirab (RIG) Human Rabies Immunoglobulin (HRIG) (in Kg) IU ML IU ML 41 1640 5. 47 820 5. Human rabies immunoglobulin (HRIG) is preferable when it is available. Rabies is a viral zoonosis transmitted in most countries of the world. Only a small quantity of equine rabies immunoglobulin (eRIG) was available from the government owned Central Research Institute (CRI) Kasauli. Annexures 1. If more than 2 mL to be given by intramuscular injection then give in divided doses at different sites, to be given in combination with rabies vaccine, not required if more than 7 days have elapsed after the first dose of vaccine, or more than 1 day after the second dose of vaccine. an attempt has been made to know the feasibility of reducing the dose of RIG in category III exposures by avoiding the calculation 2. The human rabies PM/WI 38 1503–3 M strain (inactivated). Ensure the correct strength is used for the calculation. In areas of the world where rabies is endemic, it causes an estimated 59,000 deaths per year. Rabies Vaccine. 73 860 5. 22 moderate, and 24 severe Rabies immunoglobulin and the first dose of rabies vaccine should be given as soon as possible after exposure. If immunoglobulin is not available, it can be delayed up to 7 days post 1st vaccine given. S. 112 The difference among countries is in the KEDRAB ® [Rabies Immune Globulin (Human)] is a human rabies immunoglobulin (HRIG) indicated for passive, transient post-exposure prophylaxis (PEP) of rabies infection, when given promptly after exposure, preferably at the time of the first rabies vaccine dose. 87 880 5. 1cc 6. 2273; Extra booster doses may be needed. rozanolixizumab will decrease the level or effect of rabies immune globulin, human (RIG) by receptor binding competition. These types of dosing errors can be prevented with EHR safety enhancements related to dose calculation and communication between providers and nurses regarding prescribed rabies IG administration volume at each administration site. The treatment consists of three doses of a rabies vaccine (Verorab®), which is administered prior to the person’s exposure to a An established recognized level of adequate rabies vaccination is useful for the standard evaluation of rabies biologics and basis of medical decisions; yet understanding the origins of the level and the methods used to measure The volume of rabies immunoglobulin/rabies This will help in the dose sparing use of RIG/RMAb, which Sample size calculation The proportion of category III animal exposure was considered as 63%. • Rabies vaccine should be given in the deltoid area. For PEP, two doses of rabies vaccine should be administered on days 0 and 3. Please read the entirety of this document. July 2020; Acta Tropica 211(Suppl 1) antibodies was the determining factor for dose calculation of RIG, while. Human Rabies Immunoglobulin is also given if you are at high risk of coming in contact with rabies-like veterinarians. In carefully controlled clinical studies, this globulin was used in conjunction with rabies vaccine of duck-embryo origin (DEV). The dose is the same for infants, children and adults. Rabies post exposure prophylaxis (RPEP) of previously unimmunized individuals must consist of both rabies immune globulin (RIG) and rabies vaccine. 3 Anti-Rabies Vaccines 2. Its aim is to reduce the risk after high risk exposure to rabies and give rapid protection until the rabies vaccine can become effective. Pharmacotherapy For example, a patient who misses the day 7 dose and presents on day 9 should have the day 7 dose administered that day and the day 14 dose given 7 days later (on day 16) and the following dose (if there is a 5 th dose) 14 days after that (on day 30). HyperRAB (rabies immune globulin [human]) Prescribing Information. 2 POST-EXPOSURE VACCINE (PEP) AND RABIES IMMUNOGLOBULIN (RIG) PEP is given for risk category 2 and 3 accordingly. The rabies vaccine should be given according to the 2. 4. Historically, polyclonal RIG has been used for PEP of human rabies since the mid-20th century. Because vaccines take about 2 weeks to produce sero-protective titers of When administered according to ACIP guidelines, including thoroughly infiltrating all wounds with human rabies immune globulin (HRIG), PEP is essentially 100% effective in preventing human rabies. 3. Persons who have been previously immunized with rabies vaccine and Post-exposure prophylaxis consists of a single 20 IU/kg body weight dose of KEDRAB® (Rabies Immune Globulin [Human]) and a full course of rabies vaccine. In addition, new guidance on prudent use of rabies immunoglobulins (RIG) is provided. Children and adults receive the same dose of 40 I. The equine product is now increasingly All 223 doses of rabies IG were appropriately started within 7 days of the first dose of rabies vaccine, and 98% of rabies IG doses were given on the same day as the first dose of rabies vaccine. No more than the recommended dose should be given. /Kg of body weight. The UK schedule for unimmunised individuals is 4 vaccines (+/- human rabies immunoglobulin (HRIG)) at the following intervals: 0, 3, 7 and 21 days. High dose rabies immunoglobulin may impair response to active immunization. The dose of HRIG is 20 IU/kg of body weight. Updated 'Rabies: administration of vaccine and immunoglobulin'. 3 Management of re-exposure in previously vaccinated person 3. DISCLAIMER This material is intended for use by healthcare professionals. Where applicable, a single dose of HRIG (human rabies immunoglobulin) should also be given, in a dose of 20 IU/kg infiltrated in and around the Control Manual, Chapter 1: Rabies, section 4. If it is not, equine rabies immunoglobulin (ERIG) is also effective to neutralize virus. WHO estimates that there are around 55,000 fatal cases per year, although the numbers are likely to be grossly underreported. The immunoglobulin and the anti-rabies vaccine should be administered at two different sites of the body. prophylaxis (Day 0) and rabies vaccination on Days 0, 3, 7 and 14. Human rabies immunoglobulin (HRIG) is taken from the plasma of immunised and screened human donors. Equine rabies immunoglobulin (ERIG): Dosage—40 IU/kg body weight. 60 43 1720 5. / Kg of body The calculation of the mass vaccination campaign was based on a door-to-door approach as most vaccination programs in Flores Island were carried out as door-to-door campaigns (2013, Personal communication). Pre-Exposure Prophylaxis 4. Post exposure, previously vaccinated: if immune status is unknown, the full 5 doses may be needed. 5cc Pediatric Dosages Weight in pounds (2cc/33#) Total cc Dosage Weight in pounds (2cc/33#) Rabies immune globulin is given to persons who have been exposed (eg, by a bite, scratch, or lick) to an animal that is known or thought to have rabies. Although 98% of rabies IG doses were the correct dose of within 10% of 20 IU/kg, four dosing errors were identified. People who need HRIG should receive it at the same time as the 1st dose (day 0) of rabies vaccine. Most cases occur in Africa and Asia and result primarily from canine reservoirs of rabies virus []. (+/- human rabies immunoglobulin, HRIG) at the following intervals: 0, 3, 7 and 21 days • each sequential dose should be given in alternate arms • y 0 y vaccine NOT necessarily the day of exposure • if a dose is missed, or timing has been compromised, the next vaccine should be given as soon as possible and considered as the missed dose, ABSTRACT. This is the same for infants, children and adults. 3cc / 5lbs) Adult Dosages 100 105 6. Additional doses of rabies vaccine should be given according to official guidelines or the manufacturer’s instructions. e. Market Batch No. 21 December 2021. • As with all medicines, there is a small chance that you will have an adverse reaction (or side effect) to KamRAB, such as swelling, pain at the site of injection, or an allergic Data for the calculation of the geometric mean . PRESENTATION: 100 IU/ 2. It has been compiled from information currently available and although the greatest care has been taken; the NDoH, NICD and the Rabies Working Group do not take responsibility for errors or develop, post-exposure treatment (i. recommendations about how to use vaccines to prevent disease in the United States, including how to prevent rabies in people. Even doses of ERIG as low as 0. Rabies mostly affects animals but a human can get the condition by an animal bite. 10 Treatment options for cases with skin test positivity 15 2. Repeat dosing should also be avoided as it may interfere with induction of immune response by the rabies vaccine. Methods: Multicenter, retrospective, observational review of patients that received RIG following an exposure from an animal with potential to transmit rabies infection in one health-system from March 2011 through December 2021. These studies determined that a human globulin dose of 20 IU/kg of rabies antibody, given simultaneously with Purpose: Describe a dose rounding strategy for rabies immune globulin (RIG) administration. WHO – EML has listed as Rabies Immunoglobulin until 2011, but in 2013 it has been changed to human RIG 10. A dose given before the minimum interval has elapsed will not count and will have to be repeated. 3,4 Human immunoglobulin (hRIG) is expensive and generally not available in poor rabies endemic countries. HRIG is used after high risk exposure to rabies to give rapid protection by neutralising the . For ERIG, the dose is 40 IU/kg because ERIG has a shorter half-life. 87 45 1800 6. If rabies immunoglobulin is inadvertently given, individuals will need to complete a 4 dose course of rabies vaccine (on • Subsequent doses are to be obtained through the patient’s community doctor . Talk to your doctor to see if a different vaccination schedule is needed. It is given if you are suspected of exposure to rabies after an animal bite if the animal could have rabies. 2. The equine rabies immunoglobulin is less expensive than human rabies immunoglobulin, and is used for rabies post-exposure prophylaxis in developing countries. MMWR Recomm Rep. 223. The recommended dose of Rabishield is 3. Rabies immune globulin is used only in persons who have never before received the rabies vaccine. Care Administering rabies vaccines • The dose of rabies vaccine for post-exposure prophylaxis is 1. 2. In those who are immunocompromised or taking antimalarial drugs, an additional dose is provided on Day 28. Calculate the dose of Child and adult: 20 IU/kg single dose on D0, along with the first dose of rabies vaccine. Rabies immunoglobulin administration is an integral part of the post-exposure prophylaxis and most treatment failures in patients exposed to rabid animals have been attributed to non administration of RIGs. ). 2cc 25 1. Nguyen HB, Swan JT, Howington GT. Infiltrate the area around and into the wound(s), if Administer rabies immunoglobulin. Rabies immunoglobulins: i. Administer anti-rabies vaccine immediately. Imogamrab Human Rabies Immunoglobulin, 150IU/ml; 2 ml (300 IU) ampoule provided the subsequent doses have the same minimum intervals between doses as in the original schedule. . 33 IU/kg body Weight. Table 2: Currently available human rabies immunoglobulin in India Brand Product Pharmaceuticals 1. 0 mL (Mérieux or Rabipur) or 0. 5 mL (Verorab) given by intramuscular injection. The primary outcome was to describe the RIG dose KEDRAB® (Rabies Immune Globulin [Human]) provides post-exposure prophylaxis (PEP) administering HRIG up to and including seven days after the first dose of rabies vaccine, previously vaccinated patients and any patients with a history or increased risk of hypersensitivity. 5 IU/dose was used. rozanolixizumab. Recommendations of the Advisory Committee on Immunization Practices (ACIP). 2712with a potency of > 2. 60 840 5. HYPERRAB is formulated with a strength of 300 IU/mL. 73 44 1760 5. and immunoglobulin to individuals with a The first dose should be administered as soon as possible after rabies exposure; The first dose marks the start of postexposure prophylaxis; Patients with a history of prior systemic allergic reactions to human immunoglobulin Recommended/Required Travel Vaccines. [10] It is not needed in people who have Administer post-exposure doses immediately after exposure. Reason for such change is not reported in the relevant TRS 11. Rabies Immune Globulin (Human) USP, Heat Treated, Imogam ® Rabies – HT, is a sterile solution of antirabies immunoglobulin (10-16% protein) for wound infiltration and Preparation of rabies immune globulin of human origin with adequate potency was reported by Cabasso et al. 5 ml/1 ml) or intra-dermal injection (0. 4cc 20 1. Please confirm patient weight (wt. 1. Each sequential dose should be given in Although 98% of rabies IG doses were the correct dose of within 10% of 20 IU/kg, four dosing errors were identified. Rabies PEP consists of wound washing, a dose of human rabies immune globulin (HRIG) and rabies Due to the shorter half life of eRIG, its dosage optimum was defined at 40 IU/kg, double the dose of hRIG (Rabies and World Health, 1973). Administration of rabies immunoglobulin: Improving evidence-based guidance for wound infiltration. Rabies is an incurable and inevitably fatal zoonotic disease that kills approximately 59,000 people worldwide every year. Human rabies immunoglobulin (HRIG): Dosage—20 IU/kg body weight. 2 Multiple wounds 4 RIG is not indicated. For example, if a patient misses the day seven dose and presents for vaccination on day 10, the day seven dose should be administered that day and the day 14 dose would be given 7 days later, thereby maintaining the same interval between doses. Adapted from Use of a Reduced (4-dose) Vaccine Schedule for Postexposure Prophylaxis to Prevent Human Rabies. *Only HYPERRAB ® (rabies immune globulin [human]) is indicated for postexposure prophylaxis, along with rabies vaccine, for all persons suspected of exposure to rabies. Dosage: Immunocompetent people should receive FOUR doses of rabies vaccine 1mL by IM injection on days 0, 3, 7, and 14. 1ml at 1 site) Administration of Rabies VACCINE on next page . 0 mL of Rabies vaccine. S. 1-ml doses) and a modified schedule (five 0. The recommended dose of human rabies immune globulin (HRIG) is 20 IU/kg body weight. Berirab-P Human Rabies Immunoglobulin, 150IU/ml; 2 ml (300 IU) ampoule and 5 ml (750 IU) ampoule ZLB Behring AG,Marburg, Germany/Bharat Serums and Vaccines Ltd. In the United States, most people get a series of four doses of vaccine over two weeks, and RIG is given only on the first visit. WHO-APCRI Indian Rabies Survey Rabies Post-exposure Prophylaxis (PEP) The Advisory Committee on Immunization Practices develops the U. There may be some RabIg remaining in one of the vials after administration. 1-mL Dose Form; Adjunct therapy in prophylaxis of: Rabies immunoglobulin should only be administered up to eight days after exposure as the host begins to produce sufficient antibodies to the virus one week after exposure. Coadministration of rozanolixizumab with medications that bind to the human neonatal Fc receptor may lower Administer KEDRAB as soon as possible after exposure, preferably at the time of the first rabies vaccine dose. This formula is applicable to all age groups, including children. , human rabies immunoglobulin (Berirab P) and Equine rabies immunoglobulin (Equirab). 2010; 59 (RR-2):1-9. additional vaccine doses at the correct time intervals. DOCUMENTATION: Keep accurate records of RIG and vaccine administration by recording product name, date and time of administration, dose, site(s) of administration, route(s), lot Dosage of RIG ( Rabies Immune Globulin) based on body weight Usual Dosage is 20 IU/KG of body weight or 2 cc per 33 pounds (1cc = 150 IU) (. It is imported and Day 0 is the day the first dose of rabies vaccine is administered. RABISHIELD - Rabies Human Monoclonal Antibody manufactured by Serum Institute of India. The rabies vaccine, which stimulates the body to produce its own antibodies against the rabies virus, provides protection within approximately two weeks. 13, 14 In developing countries of Asia, This was done mainly to see if the dose calculation based on body weight is really applicable Administer rabies immunoglobulin 3. Table 1. 00 rabies immunoglobulin product to prevent infections resulting from the use of medicinal products prepared from human blood or plasma. 2 Rabies Immunoglobulin (RIG) 2.